Dr Jekyll and Mr Hyde’ of exocrine gland carcinomas: Breast adenoid cystic carcinoma - A rare entity

Adenoid cystic carcinomas of the breast and salivary glands (or 'The strange case of Dr Jekyll and Mr Hyde' of exocrine gland carcinomas).

Adenoid cystic carcinoma (AdCC) is a tumour with myoepithelial differentiation and characterised by the presence of a dual population of basaloid and luminal cells arranged in specific growth patterns. These tumours, regardless of the anatomical site, are characterised by expression of the proto-oncogene and therapeutic target c-KIT, and seem to harbour a specific chromosomal translocation t(6;...

Tamoxifen: Dr. Jekyll and Mr. Hyde?

Without regard to patient selection, other than the eligibility requirements for entry into the studies, worldwide overviews of prospective clinical trials demonstrate that adjuvant tamoxifen reduces the annual odds of death for women with invasive breast cancer by approximately 15% over 10–15 years (1). These data raise the provocative question: Should all patients with invasive breast cancer ...

Factor V: a combination of Dr Jekyll and Mr Hyde.

The desirable process of hemostasis and the undesirable phenomena of thromboses are unequivocally consequences of the generation of thrombin by the prothrombinase complex. This stoichiometric complex of factor Xa and factor Va assembled on a platelet membrane converts membrane-bound prothrombin into its active products by 2 sequential peptide-bond cleavages. The functionality and durability of ...

Two Honeysuckles: A Tale of Dr. Jekyll and Mr. Hyde

TGN1412: Superagonist Dr. Jekyll and Superantigen Mr. Hyde

Los anticuerpos anti-CD28 superagonistas inducen activación de los linfocitos T en ausencia de estimulación del TCR. Los ensayos clínicos de uno de tales anticuerpos, TGN1412, han resultado en severas complicaciones en los voluntarios que lo recibieron. El análisis de las características y modo de acción de los superagonistas de CD28 sugiere que dichos efectos son similares a los previamente ob...